Oncogenic drivers and mitochondrial dependency
نویسندگان
چکیده
منابع مشابه
Oncogenic drivers and mitochondrial dependency
metabolically targeted approaches to cancer therapy have focused on the reliance of cancer cells on glycolysis for energy metabolism. The Warburg effect is thought to minimize the role of mitochondrial metabolism in the survival of cancer cells. We recently demonstrated that BCR-ABL-driven leukemic cells become reliant on the TCA cycle for energy production upon inhibition of the dominant tyros...
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Cancer is a genetic disease caused by a series of somatic and/or germline mutations. The roles of oncogenes and tumor suppressors in cancer molecular origin have been well established. Targeting oncogene products has become an attractive therapeutic strategy with great clinical success, whereas tumor suppressors are considered 'undruggable' because current technology is not able to restore tumo...
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With a diameter of ~30 nm and a mass of ~4.3 MDa, human ribosomes are structurally and functionally sophisticated cytoplasmic giants. Half of this mass comes from the 81 ribosomal proteins (RPs) which, formerly erroneously believed to simply act as dispensable assistants of the catalytic ribosomal RNA (rRNA), are in many cases essential for ribosomal functioning. Ribosomes can mechanistically b...
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Rho GTPases impact a number of activities important for oncogenesis. We describe a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma cells, without affecting normal cells. We identify the target of this inhibitor to be the metabolic enzyme glutaminase, which catalyzes the hydrolysis o...
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ژورنال
عنوان ژورنال: Aging
سال: 2015
ISSN: 1945-4589
DOI: 10.18632/aging.100734